Tweeter button Delicious button Digg button Stumbleupon button
Alcohol Liver Disease | Researchers Foresee New Treatments And Diagnostics For Deadly Fibrotic Diseases Of The Lung, Liver, And Kidney

Jan. 9, 2013 — A team of scientists has developed a playbook for ending the devastating impact of fibrotic diseases of the liver, lung, kidney, and other organs, which are responsible for as many as 45 percent of all deaths in the industrialized world. Despite the prevalence of these illnesses, which are caused by buildup of scar tissue, there are no approved antifibrotic drugs on the market in the U.S.

A top fibrosis expert from the Icahn School of Medicine at Mount Sinai and three other institutions have described drug targets and compounds they hope will prove broadly effective in an article, “Therapy for Fibrotic Diseases: Nearing the Starting Line,” appearing in the January 9 issue of Science Translational Medicine .

Scientists and drug companies are taking important steps to address the unmet need for fibrosis treatments. Among other advances, researchers have discovered and started to validate biomarkers that will facilitate testing of new drugs in clinical trials, according to the article.

“The insights we have described lay the groundwork for a new understanding of treatment approaches and diagnostics,” said Scott Friedman, MD, the Dean for Therapeutic Discovery at Mount Sinai and lead author of the article. Diseases such as pulmonary fibrosis, renal fibrosis and hepatic cirrhosis represent “a huge unmet medical need,” said Dr. Friedman, who is also the Director of the Division of Liver Diseases and its Centers for Fibrosis Research and Alcohol Liver Disease. “New treatments that are already in clinical trials exemplify a range of strategies harnessed by several pharmaceutical and biotechnology companies.”



alcohol liver disease

Addiction Free Forever Program.

Is alcohol or drug use badly affecting your life or someone’s life who you care about?

The Addiction Free Forever Program is guaranteed to show how to permanently end an alcohol or drug problem and have a deeply fulfilling life naturally…

It’s not realistic to expect someone to permanently “say no to drugs” unless they have something better to say “yes” to…

Read More: Visit Publisher Site

In the past, the fibrosis field has suffered from a lack of communication among disease experts focused on individual organs, and scientists did not fully consider similarities in cellular dysfunction found in all fibrotic diseases. However, growing synergies across medical specialties have sharpened the perspective on how fibrotic diseases are triggered by injury to epithelial tissues — the layers of densely packed cells that line all the organs of the body.

Recent research has produced a more coherent, comprehensive view of how these tissue injuries provoke dysregulation of cell differentiation, signaling, and protein secretion, Dr. Friedman said. “Investigators across the field are putting aside organ-centric views and coming up with what we think are the overarching characteristics of fibrosis. Understanding how the disease develops can help us diagnose and treat it, regardless of where in the body the fibrotic tissue presents,” said Dr. Friedman, who co-authored the review article with colleagues from the University of California, San Francisco, the University of Washington, Seattle and Biogen Idec, based in Cambridge, Mass.

Dr. Friedman estimated that hundreds of clinical trials are currently underway, testing dozens of antifibrotic drugs. Some of the most promising studies focus on blocking a pathway driven by a molecule known as TGFß, which was identified more than 20 years ago as a central mediator of fibrosis. While there have been concerns that inhibiting this pathway could also


Click here to view rest of article from original site


Facebook Twitter Email

Important Disclaimer: Article Comments provided are for general information purposes only and are not intended to substitute for informed professional medical, psychological, tax, accounting, legal, investment, or any other professional advice. We expressly disclaim liability for any product, manufacturer, distributor, service or service provider mentioned or any opinion expressed in these comments or anywhere else within the site. Lastly, we do not endorse any article or comment. Use at your own risk.