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Cirrhosis | International Partners To Seek Genes Involved In Cirrhosis

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) ” The National Institute on Alcohol Abuse and Alcoholism has provided $2.5 million to fund an international project that will search for genetic variants that may predispose some heavy drinkers to developing alcoholic liver cirrhosis, or ALC, while others do not.

The project will involve a multidisciplinary group of partners in the US, Australia, France, Germany, Switzerland, and the UK who will collect and analyze clinical data from 1,250 heavy drinkers with ALC and 1,250 who do not have the disorder.


They also will study clinical data from 2,700 heavy drinkers from existing databases and repositories, and the subjects will be matched for other factors, such as age, race, and nationality.

The study will be led by principal investigator Timothy Morgan, a professor of medicine at the University of California, Irvine and Chief of Hepatology at VA Long Beach Healthcare System.

The subjects’ DNA will be genotyped using the Illumina Human 660-Quad SNP array at the Center for Inherited Disease Research at Johns Hopkins University. The data will be analyzed and


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