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Fatty Liver Disease | Patients With Nonalcoholic Fatty Liver Disease Have Less Occurrence Of Liver …

Worldwide, NAFLD has become the most frequent cause of chronic liver disease, and investigations have reported up to 30% of the general population and 75% of obese people have the disease. A minority of individuals with the disease develop fibrosis or cirrhosis of the liver, and non-alcoholic fatty liver disease together with advanced fibrosis or cirrhosis can result in hepatic-related complications, liver cancer , liver failure or death. Even though the number of cases of the disease has increased, investigations have been limited regarding the natural history of the disease together with advanced fibrosis or cirrhosis and later outcomes.

Lead author Dr. Neeraj Bhala from the University of Oxford in the UK, said: “Our study reports on the long-term morbidity and mortality of NAFLD patients with advanced fibrosis or cirrhosis by prospectively following up cases from four international collaborating hepatology centers. Understanding the long term prognosis of NAFLD patients compared with patients affected by other liver diseases such as chronic HCV was an important aspect of our study.” According to medical evidence although HCV is at present the primary indicator for liver transplantation, which affects over 5 million people in the U.S., the frequency of HCV has leveled, while the prevalence for NAFLD is increasing.


Researchers enrolled 247 individuals with NAFLD in the largest prospective investigation up to now of people with advanced fibrosis or cirrhosis. They also enrolled 264 individuals with HCV infection who had not been treated previously or who were unresponsive to treatment from centers in Australia, Italy, the UK and the USA. Verified by liver biopsy at the start of the investigation, participants in both groups were Child-Pugh class A and had advanced fibrosis (stage 3) or cirrhosis


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