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Liver Disease | Siemens Launches A New 60 Minute Blood Test For Earlier Detection Of Liver Damage

LONDON, August 1, 2011 /PRNewswire/ —

According to official figures from the Department of Health, alcoholic liver disease in the under 30s has risen by 50 per cent in the last ten years.

Liver disease is now the countrys fifth biggest killer. The coalitiongovernment wants a “drink strategy” with input from both the health lobby and the drinks industry.

Siemens Healthcare Diagnostics is helping patients suffering from liver disease, with the launch of the first automated liver fibrosis test – an important indicator of Chronic Liver Disease.

Doctors in primary care are flooded with patients with obesity and hazardous drinking, all of whom could be at risk of chronic liver disease. The use of a simple blood test to accurately identify those with significant liver disease will greatly aid triage and the appropriate targeting of interventions including weight loss, exercise, and therapeutic interventions.

Liver fibrosis refers to the accumulation of tough, fibrous scar tissue in the liver. The formation of this tissue (through the deposition of new collagen) is a normal bodily response to injury, but in fibrosis this healing process goes awry.

The traditional reference standard for detecting and assessing liver fibrosis has been trans-abdominal needle biopsy of the liver. Small sample size and the patchy distribution of some liver pathology can result in a significant degree of sampling error. Also, the procedure can be painful and hazardous; bleeding is caused in approximately one in 1000 cases and death in one in 10,000 cases. This also results in a high cost to the NHS with patients requiring an overnight stay in hospital at a cost of approximately GBP1,000.

This first fully automated standardised direct biomarker panel offers doctors a quick, reliable, minimally invasive blood test option to assess liver fibrosis – an important indicator of Chronic Liver Disease (CLD) – with results in less than one hour. With the addition of the ELF test, Siemens is currently the only company to offer an integrated portfolio of diagnostic solutions for managing liver health, which includes routine chemistry tests, hepatitis serology tests, viral load testing, and ultrasound systems.

Chronic liver disease, resulting from alcoholic liver disease, fatty liver, or viral hepatitis, is increasingly recognised as a major cause of morbidity and mortality. Standard liver function tests do not accurately reflect the true extent of fibrotic damage or, in many cases, may detect it too late.

Fibrosis is a common outcome in chronic liver disease, with progression to cirrhosis accounting for thousands of deaths each year. Liver biopsies are routinely performed to assess liver damage (fibrosis) and to try to monitor the effectiveness of pharmaceutical drugs in tackling the disease. Performing a liver biopsy is a hazardous, expensive and painful experience for the patient and does not always provide accurate results because of difficulties in sampling and interpretation. Fibrosis is not evenly distributed throughout the liver and because such a small amount of biological material is sampled, 55 percent of 15mm biopsies may be misclassified. Larger biopsies can be performed but even with 25mm sections, 45 percent will be erroneous.

The discovery of the ELF markers represents a significant advance in the diagnosis of

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