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Liver Diseases | Survival Improved By Use Of Living Donor Liver Transplantation Compared To …

Severity can range from mild to life-threatening liver failure for liver diseases, such as hepatitis B and C, nonalcoholic fatty liver disease, and HCC. Liver transplantation is the recommended procedure when a patient’s life is at risk from end-stage liver disease. According to the Organ Procurement and Transplant Network (OPTN), since September 2011 over 16,000 individuals in the U.S. are on the waiting list for a liver transplant. The OPTN reported that 3,108 liver transplants were performed in the U.S. between January and June 2011, with roughly 96% being DDLTs and 4% LDLTs.

Prior investigations discovered evidence that LDLT is connected with improved survival in comparison with waiting for DDLT, however, it is still unsure if this benefit persists in individuals with low MELD scores (less than 15). Chief author Carl Berg, M.D., with the University of Virginia Health System, said: “In order to better inform liver transplant candidates of survival outcomes, our study investigated the mortality risk of undergoing transplantation using livers from living donors versus waiting to receive a deceased donor organ.”


For the current investigation, data on individuals listed for liver transplant as well as potential donors were supplied by transplant centers that were involved in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. The study included 868 adults who were listed for liver transplantation and were on average followed for 4.6 years. Living donors of the investigation participants were examined between February 2002 and August 2009 – the period following MELD-based liver allocation. Individuals who received DDLT at study centers were obtained for comparison during the same time period.

Mortality was compared between individuals who received LDLT and those who were still on the waiting list or who had received DDLT, with categories of MELD score lower or greater than 15, and liver cancer


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